Detailed genomic characterization identifies high heterogeneity and histotype-specific genomic profiles in adrenocortical carcinomas
نویسندگان
چکیده
منابع مشابه
Genomic heterogeneity in synchronous hepatocellular carcinomas.
BACKGROUND Hepatocellular carcinoma (HCC) arising in cirrhosis is frequently multifocal. Whether HCC develops monoclonally or multiclonally is an unresolved question. Of the multiple tumour nodules present in many patients, it has not been established whether the smaller lesions represent intrahepatic metastases or de novo cancers. AIMS To assess the degree of genomic heterogeneity in synchro...
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Multiple myeloma is an incurable plasma cell malignancy with a complex and incompletely understood molecular pathogenesis. Here we use whole-exome sequencing, copy-number profiling and cytogenetics to analyse 84 myeloma samples. Most cases have a complex subclonal structure and show clusters of subclonal variants, including subclonal driver mutations. Serial sampling reveals diverse patterns of...
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The nature and pace of genome mutation is largely unknown. Standard methods to investigate DNA-mutation rely on arraying or sequencing DNA from a population of cells, hence the genetic composition of individual cells is lost and de novo mutation in cell(s) is concealed within the bulk signal. We developed methods based on (SNP-) arraying and next-generation sequencing of single-cell whole-genom...
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BACKGROUND Fibrolamellar carcinoma (FLC) is a variant of hepatocellular carcinoma (HCC) with distinctive clinical and histological features. To date there have been few studies on the genotypic aspects of FLC and no previous attempts have been made to use the arbitrarily primed-polymerase chain reaction (AP-PCR) technique to detect genetic alterations in this disease. AIM The aim of this stud...
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a Department of Biology, Wesleyan University, Middletown, CT 06459-0170, USA 10 b Department of Biology, University of Virginia, P.O. Box 400328, Charlottesville, VA 2290411 4328, USA 12 * These authors contributed equally to this work. 13 † Present address: Public Interest Network, Boston, MA. 14 ‡ Present address: Department of Biochemistry, University of California, San Francisco, CA. 15 16 ...
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ژورنال
عنوان ژورنال: Modern Pathology
سال: 2018
ISSN: 0893-3952,1530-0285
DOI: 10.1038/s41379-018-0042-6